Resumen: When connecting a renewable energy source to a medium-voltage grid, it has to fulfil grid codes and be able to work in a medium-voltage range (>10 kV). Multilevel converters (MLCs) are recognized for their low total harmonic distortion (THD) and ability to work at high voltage compared to other converter types, making them ideal for applications connected to medium-voltage grids whilst being compliant with grid codes and voltage ratings. Cascaded H-bridge multilevel converters (CHBs-MLC) are a type of MLC topology, and they does not need any capacitors or diodes for clamping like other MLC topologies. One of the problems in these types of converters involves the double-frequency harmonics in the DC linking voltage and power, which can increase the size of the capacitors and converters. The use of line frequency transformers for isolation is another factor that increases the system’s size. This paper proposes an isolated CHBs-MLC topology that effectively overcomes double-line frequency harmonics and offers isolation. In the proposed topology, each DC source (renewable energy source) supplies a three-phase load rather than a single-phase load that is seen in conventional MLCs. This is achieved by employing a multi-winding high-frequency transformer (HFT). The primary winding consists of a winding connected to the DC sources. The secondary windings consist of three windings, each supplying one phase of the load. This configuration reduces the DC voltage link ripples, thus improving the power quality. Photovoltaic (PV) renewable energy sources are considered as the DC sources. A case study of a 1.0 MW and 13.8 kV photovoltaic (PV) system is presented, considering two scenarios: variations in solar irradiation and 25% partial panel shedding. The simulations and design results show the benefits of the proposed topology, including a seven-fold reduction in capacitor volume, a 2.7-fold reduction in transformer core volume, a 50% decrease in the current THD, and a 30% reduction in the voltage THD compared to conventional MLCs. The main challenge of the proposed topology is the use of more switches compared to conventional MLCs. However, with advancing technology, the cost is expected to decrease over time.