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dc.contributor.author Von Bernhardi Montgomery, Rommy Edith
dc.contributor.author Dulcey, Andrés
dc.contributor.author Hu, X
dc.contributor.author Dextras, C
dc.contributor.author Talley, D
dc.contributor.author Álvarez Rojas, Alejandra
dc.contributor.author Zanlungo, Silvana
dc.date.accessioned 2023-12-22T06:04:42Z
dc.date.available 2023-12-22T06:04:42Z
dc.date.issued 2023
dc.identifier.citation Von Bernhardi Montgomery , R E , Dulcey , A , Hu , X , Dextras , C , Talley , D , Álvarez Rojas , A & Zanlungo , S , C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same. , Patente N.º US11649218B2 .
dc.identifier.uri https://repositorio.uss.cl/handle/uss/8633
dc.description.abstract Disclosed herein are embodiments of a compound that inhibits c-Abl tyrosine kinase (also referred to herein as “c-Abl”). The compound embodiments described herein are novel c-Abl inhibitors that can bind to c-Abl at an allosteric site and inhibit its activity in various pathways. The compound embodiments also are capable of crossing the blood brain barrier and therefore are useful in inhibiting c-Abl activity as it affects pathways and/or proteins in the brain. The compound embodiments described herein are effective therapeutic agents for treating diseases involving c-Abl, such as cancers, motor neuron diseases, and neurodegenerative diseases. Also disclosed herein are embodiments of methods for making and using the c-Abl inhibitory compound embodiments es
dc.language.iso spa
dc.title C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same. es

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